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Chemtrix

Continuous Flow Reactors / Micro Reactors

Flow reactors (micro reactors) are devices in which chemical reactions take place in micro channels. Microreactors are continuous flow reactors (in contrast to batch reactors), whereby the chemical reaction happens continuously (flow synthesis). Microreactors offer many advantages over conventional batch reactors, including vastly improved heat transfer, increased control of reaction kinetics, higher yields (less side-reactions and impurities), improved operational safety and higher energy efficiency.
We offer various micro reactors systems made of borosilicate glass, ceramic (silicon carbide SiC) and 3D printed metal (stainless steel). The size range covers flow reactors that are suitable for lab-scale reactions at milligram to gram scale (LABTRIX®, GRAMFLOW®), pilot-scale reactions at gram to kilo scale (KILOFLOW®, PROTRIX®), as well as production-scale reactions at kilo to multi-ton scale (PLANTRIX®).


Chemtrix
Temperature range: -20 °C to 195 °C
Pressure tolerance: ≤ 25 bar

Labtrix® Start is a manual, low cost platform for laboratory based optimization of reactions within glass micro reactors. It is delivered with two to five pumps, employing three feed lines and is suitable for type reactions up to A+B=P1+Q=P.

Three different models are available employing PEEK, PPS or ETFE wetted parts, depending on the level of chemical resistance required against corrosive and hazardous reagents. More information

Chemtrix
Temperature range: -20 °C to 195 °C
Pressure tolerance: ≤ 25 bar

Labtrix®-S1 System (supplied with laptop and software) is a fully automated, standardized platform for laboratory based reaction screening using continuous flow chemistry, including optimization, kinetic data generation, process feasibility studies, process validation and additive screening. It can perform several hundred experiments per day with minimal use of raw materials (< 50 mg for 100 data points) and is delivered with 5 different pre-defined micro reactors, enabling a diverse range of (hazardous) synthetic reactions. Each system includes five pumps (pumps 4 and 5 can be linked for continuous delivery), automated sample collection for 30 vials and is suitable for type reactions up to A+B+C=P1+D=P2+Q=P.

Two different models are available employing PEEK and ETFE wetted parts, depending on the level of chemical resistance required against corrosive and hazardous reagents. More information

Chemtrix
Fabricated from borosilicate glass, GramFlow® flow reactors have integrated pre-heat & heat exchange giving optimal thermal control for challenging flow chemistry applications. The system can process up to 1200 grams per day.

It is the perfect solution for scale up from mg to g. Benefits include reaction screening and g-scale production as well as excellent mixing results due to zig-zag structure. Wetted materials are made of PTFE, FFKM and Borosilicate Glass. More information

Chemtrix
KiloFlow® is a pilot flow reactor system (flow reactor used in combination with pumps, heat exchangers, temperature control and pressure regulation) that is designed to readily access extreme temperatures (-15 °C to 150 °C), reaction times and pressure conditions (up to 20 bar). KiloFlow® enables previously ‘forbidden’ transformations to be executed within a conventional laboratory, and is ideal for up-scaling with no change in mixing efficiency.

Two sizes of reactor modules are available. A single channel reactor with a volume of 0.8 ml (RS) and a parallel channel reactor with a volume of 6.5 ml (RL). Wetted parts are made of PEEK, ETFE and glass. KiloFlow® can be delivered with three levels of process control: Manual, Automated, Automated GMP. More information

Chemtrix
Protrix® is a lab-scale ceramic (SiC) flow reactor, suited for chemical process development. With Protrix® processes can be developed in the lab and directly scaled to ton-scale production using Plantrix® MR555. It offers superior chemical resistance and heat transfer needed for challenging flow chemistry applications. Its modular set up allows for different working volumes. More information

Chemtrix
3D-printed flow reactors, made of 316L stainless steel, are ideal for high pressure (<100 bar) and high temperature (-100°C to 300°C) flow chemistry applications.

Chemtrix supplies a range of standard 3D printed metal flow reactors, suited for process development and production on kilo-scale. The possible customization of the 3D printed reactors also enables a scale-up to production scale.

Reaction Types: A+B → P1 + C → P
Throughput: 12.5 to 200 ml/min (up to 12 kg/h)
Volume: 1, 2, 4 and 8 ml modules
Wetted Materials: 316L stainless steel More information